Analysis of tumor cell plasticity in endometrioid carcinoma using cancer stem cell marker aldehyde dehydrogenase (ALDH)

To investigate the tumor cell plasticity using aldehyde dehydrogenase (ALDH) 1A1 activity, we established two distinct HEC-1B sublines, in which ALDH1A1-high population accelerated such transition and ALDH1A1-high population did not show such acceleration. Overall design: Comparative gene expression profiling analysis of RNA-seq data for HEC-1B cells confirmed the presence or absence of acceleration of transition from ALDH1A1-low to ALDH1A1-high population by Fluorescence-activated cell sorting (FACS).