Context Dependency of Set1/COMPASS Mediated H3 Lysine 4 Trimethylation

The stimulation of trimethylation of histone H3 lysine 4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied with multiple mechanisms proposed for this form of histone crosstalkH2B单泛素化（H2B monoubiquitination，H2Bub）对组蛋白H3赖氨酸4三甲基化（trimethylation of histone H3 lysine 4，H3K4）的促进作用已得到广泛研究，针对这类组蛋白串扰形式，学界已提出多种作用机制。