Intrapartum Nitrous Oxide: Satisfaction, Side Effects, and Predictors of Conversion

In 2015, the Intrapartum Nitrous Oxide Workgroup (I-NOW group) designed a multi-institutional database, Intrapartum Nitrous Oxide Database (I-NOW database), to collect data on births during which N2O was used. The goal of compiling data on N2O use from a variety of U.S. institutions was to evaluate unaddressed aspects of intrapartum N2O use with a focus on safety and best-use practices. This dataset holds data from one institution in the workgroup for 463 intrapartum adult (≥ 18 years old) patients who used nitrous oxide. The data points include demographics, medical history, obstetric history, side effects and satisfaction scores for nitrous oxide, conversion to other methods, and reasons for conversion. Labor induction, medical augmentation, parity, trial of labor after cesarean delivery (TOLAC), and post-nitrous cervical dilation all had significant effects on the rate of conversion to neuraxial analgesia. Side effects related to inhaled N2O use during labor were rare and were not a significant reason for conversion to neuraxial analgesia. Newborn Apgar scores averaged 8 and 9 at 1 and 5 minutes respectively.

2015年，产时一氧化二氮工作组（Intrapartum Nitrous Oxide Workgroup，简称I-NOW工作组）搭建了多机构数据库——产时一氧化二氮数据库（Intrapartum Nitrous Oxide Database，I-NOW数据库），用于收集使用一氧化二氮（N₂O）的分娩相关数据。该数据库旨在汇集美国多家医疗机构的一氧化二氮使用数据，以评估产时一氧化二氮使用中未被充分关注的维度，重点聚焦安全性与最佳临床实践规范。本数据集取自该工作组内1家机构的临床数据，涵盖463名年龄≥18岁的成年产时患者，这些患者均使用了一氧化二氮镇痛。数据字段包含人口统计学信息、病史、产科病史、一氧化二氮相关不良反应与满意度评分、转为其他镇痛方式的情况及转换原因。研究分析显示，引产、医学催产、产次、剖宫产后阴道试产（Trial of Labor After Cesarean Delivery，TOLAC）以及使用一氧化二氮后的宫颈扩张程度，均对转为神经轴阻滞镇痛的比例存在显著影响。分娩期间吸入一氧化二氮引发的不良反应较为罕见，且并非导致患者转为神经轴阻滞镇痛的重要诱因。新生儿1分钟、5分钟的阿普加评分（Apgar Score）均值分别为8分与9分。

搜集汇总

背景与挑战

背景概述

该数据集聚焦分娩期一氧化二氮（N2O）使用的临床研究，包含463名成年患者的数据，涵盖人口统计、病史、副作用、满意度及转换到其他镇痛方法的原因。关键特点包括：数据集旨在评估一氧化二氮使用的安全性和最佳实践，发现分娩诱导、产次等因素显著影响转换率，而副作用罕见且新生儿Apgar评分正常（平均1分钟8分、5分钟9分），表明一氧化二氮在分娩中相对安全。