Regression analysis for Glucosylsphingosine.

The analysis included all 19 patients for whom values before and after ERT were available, details on the course of Glucosylsphingosine values are shown in Figure 5. Time point zero represents the first value after onset of therapy. The table shows regression based (linear mixed models) predicted values for Glucosylsphingosine and reduction in % compared to 6 months before therapy. To overcome the skewed distribution of measurements Glucosylsphingosine values were logarithmised before regression analysis. Glucosylsphingosine was reduced after onset of ERT. The largest reduction occurred within the first 6 months after starting the ERT therapy. Patients display a reduction of 47.8% after 6 months and of 43.1% after 60 months of therapy.