Characteristics of specific nonsynonymous variants in four geographic haplogroups observed in 300 OSCC patients.

aFive methods including the PolyPhen-2 and SIFT (Sorting Intolerant From Tolerant) algorithm, the Grantham and BLOSUM 62 matrix, and the degree of evolutionary conservation wer applied to predict the putative effect of each nonsynonymous variant on protein function. Variant on protein function predicted to be significantly impacted is presented in bold phase.bcases with variant/cases in the defined haplogroup.cT: tolerated; D:deleterious.dEC: evolutionary conserved; EU: evolutionary unconserved.