SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity.

Sema3A，作为一种典型的信号蛋白，能够通过激活由神经突触蛋白1作为配体结合亚单位和plexin-A1作为信号转导亚单位组成的受体复合物，充当轴突的化学排斥剂或化学吸引剂。Sema3A通过抑制整合素配体结合活性来抑制细胞迁移。