Extracellular stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids

Excel folder containing the original data for the study “Extracellular stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids.” Regional epithelial lineages of the human respiratory system reside within an extracellular matrix whose mechanics vary along the airway-alveolar axis, yet how extracellular stiffness directs epithelial fates remains unclear. Here, utilizing human pluripotent stem cells derived lung organoids embedded in stiffness-tunable hydrogels as an in vitro model, we show that extracellular stiffness governs region-specific epithelial differentiation.