Enantiocontrol with a Hydrogen-bond Directing Pyrrolidinylsilanol Catalyst
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Enantiocontrol_with_a_Hydrogen_bond_Directing_Pyrrolidinylsilanol_Catalyst/2499346
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资源简介：
A new bifunctional catalyst containing a silanol group has been designed and synthesized with high enantioselectivity in three steps. The hydrogen-bonding properties of this pyrrolidinylsilanol have been investigated using NMR binding studies and electrospray ionization mass spectrometry (ESI-MS) analysis. The ability of the silanol group to activate an electrophile and afford enantiocontrol through hydrogen-bond directing effects has been demonstrated using an enantioselective aldol reaction with isatin and acetaldehyde, affording up to 88% ee.
创建时间：
2016-02-20
