Parameter A as a Motif-Scale Transport Coordinate: Target Vulnerability and Central-Path Modulation on Human Routing Motifs

Complete dataset, analysis code, and documentation for a systematic characterization of Parameter A = ln(R₀/R₀_edge) as a motif-scale transport coordinate on human structural connectomes.* Parameter A quantifies the dephasing-assisted transport advantage (ENAQT) on routing motifs extracted from HCP diffusion MRI connectomes (Lausanne scale-125, 234 regions, N = 15–1064 subjects depending on analysis). This bundle documents a research program comprising behavioral screening, structural baseline analysis, perturbation vulnerability mapping, selectivity profiling, source-state sensitivity, disorder interaction, and a cross-species boundary test on Drosophila mushroom body. Key findings: A predicts target-cluster vulnerability on both thalamocortical (T3L) and basal ganglia (T2L) routing ports: Spearman ρ = −0.67 to −0.69, p < 0.01, with topology-specificity ratios of 3.9–4.7× (highest- vs lowest-degree target removal). Corrected central-path perturbations (hub deletion, corridor weakening) produce topology-specific effects 3–6× larger than matched random controls (Wilcoxon p < 0.003), with a mechanistic signature distinct from target vulnerability: target removal decreases A through preferential R_peak loss; corridor weakening predominantly increases A through differential R_peak enhancement. Under site-energy disorder, the perturbation hierarchy undergoes a crossover near ε ≈ 1, where corridor sensitivity surpasses target vulnerability (medianized over 10 disorder seeds). On multi-source dense motifs (T2, 3 sources), A requires mixed (incoherent) initialization: coherent source superposition eliminates the ENAQT window (198/200 alive under mixed init vs 195/200 dead under coherent init, N = 100). A does not predict cross-subject cognitive outcomes (0/3, p > 0.43, N = 1064; pre-registered AsPredicted #281717). Cross-species test on Drosophila mushroom body (N = 243 neurons) returned a negative: no robust interior peak under medianization, establishing dense bottleneck architecture as a boundary condition for A. Bundle contents: 38 data CSV files (23 paper results, 9 diagnostic/audit trail, 6 Drosophila MB), 22 Python scripts, 6 figures (PDF + PNG), research protocol (615 lines), draft preprint (221 lines), SHA256 manifest. All scripts self-contained and executable. Companion papers: Paper 1 (Stage-II): doi:10.5281/zenodo.19056201 Paper 2 (Cross-species): doi:10.5281/zenodo.19222237