Selected categories significantly over-represented in <i>PIK3CA</i>-mutated breast tumors.

ns: not significant. The biological processes, molecular functions and physiological pathways of genes were obtained from the DAVID database using GOTERM_BP_FAT, GOTERM_MF_FAT and KEGG PATHWAY, respectively. The two first tools (Gene Ontology) annotated 4202 genes (1630 up- and 2672 down-regulated genes) while KEGG annotated 960 genes (385 up- and 601 down-regulated genes). The gene enrichment of a given class was measured by determining the number of genes belonging to the class in the list of significantly altered genes, weighed against the total human genome, and was tested using Fisher exact probability test. Not all significant categories are included here in order to reduce redundancy. A given gene can belong to several processes.