Late transcriptional changes in blood, neural, and colon tissues in rat stress alone and comorbid pain model compared with naïve have regulatory roles in neurological disease

Conclusions: Our study highlights an increased inflammatory response in CPH compared to SIH rats in the blood and colon. DRG and spinal transcriptomic profiles of both CPH and SIH rats showed inhibition of synaptic activity along with activation of angiogenesis. Targeting these biological processes may lead to more profound understanding of the mechanisms underlying IBS-TMD comorbidities and new diagnostic and therapeutic strategies结论：本研究表明，相较于SIH大鼠，CPH模型大鼠的血液与结肠组织中炎症反应显著增强。对CPH与SIH大鼠的背根神经节（Dorsal Root Ganglion, DRG）及脊髓转录组谱进行分析后可见，两类大鼠均呈现突触活动受抑制、血管生成被激活的特征。靶向调控上述生物学过程，或可加深对肠易激综合征（Irritable Bowel Syndrome, IBS）合并颞下颌关节紊乱病（Temporomandibular Disorder, TMD）共病潜在机制的理解，并助力开发全新的诊断与治疗策略。