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Gene expression in Mon-Mac-6 cells treated with METTL3 PROTAC, WD6305

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE234985
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We developed a new METTL3 PROTAC, WD6305, which, unlike inhibitors, can reduce the expression of METTL3 protein. Here, we tested the gene expression after dosing by RNA-seq. In order to detect the gene expression changes of Mon-Mac-6 after treatment with WD6305, we sequenced Mon-Mac-6 cells after treatment with 500nM DMSO and WD6305 for 48h.
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2023-11-29
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