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Heme/Copper Assembly Mediated Nitrite and Nitric Oxide Interconversion

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NIAID Data Ecosystem2026-03-07 收录
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https://figshare.com/articles/dataset/Heme_Copper_Assembly_Mediated_Nitrite_and_Nitric_Oxide_Interconversion/2466913
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The hemea3/CuB active site of cytochrome c oxidase is responsible for cellular nitrite reduction to nitric oxide; the same center can return NO to the nitrite pool via oxidative chemistry. Here, we show that a partially reduced heme/Cu assembly reduces NO2– ion, producing nitric oxide. The heme serves as the reductant, but the CuII ion is also required. In turn, a μ-oxo heme-FeIII–O–CuII complex facilitates NO oxidation to nitrite; the final products are the reduced heme and CuII–nitrito complexes.
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2016-02-20
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