Differential expression of bone marrow derived mesenchymal stem cells in patients with multiple myeloma. Differential expression of bone marrow derived mesenchymal stem cells in patients with multiple myeloma

Bone marrow-derived mesenchymal stem cell (BMSC) is one crucial component of the multiple myeloma (MM) microenvironment and supports the malignant progression of MM. Whether BMSCs act on MM cells via exosomes has not been well characterized. Herein, we used microarrays to screen out differentially expressed miRNAs in BMSCs from patients with MM (MM-MSCs) or benign diseases (BD-MSCs). Overall design: 2 pairs of bone marrow derived MSCs from MM patients and bone marrow derived MSCs from benign disease patients