Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.
收藏PubMed Central1995-07-03 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC41570/
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资源简介：
Cerebral cavernous malformation is a common disease of the brain vasculature of unknown cause characterized by dilated thin-walled sinusoidal vessels (caverns); these lesions cause varying clinical presentations which include headache, seizure, and hemorrhagic stroke. This disorder is frequently familial, with autosomal dominant inheritance. Using a general linkage approach in two extended cavernous malformation kindreds, we have identified linkage of this trait to chromosome 7q11.2-q21. Multipoint linkage analysis yields a peak logarithm of odds (lod) score of 6.88 with zero recombination with locus D7S669 and localizes the gene to a 7-cM region in the interval between loci ELN and D7S802. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-07-03
