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Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

ChEBI2010-04-08 更新2026-07-21 收录

亨廷顿病机制研究

神经退行性疾病治疗

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-21237 数据链接链接失效反馈

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Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

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创建时间：

2010-04-08

靶向药物研发

神经退行性疾病治疗

In this paper, we applied an innovative nuclear magnetic resonance (NMR)-guided screening and ligand design approach, named focused high-throughput screening by NMR (fHTS by NMR), to derive potent, lo

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Table_1_Breached Barriers: A Scoping Review of Blood-Central Nervous System Barrier Pathology in Amyotrophic Lateral Sclerosis.DOCX

ALS血脑屏障病理

神经退行性疾病治疗

IntroductionRecent studies have implicated changes in the blood-central nervous system barriers (BCNSB) in amyotrophic lateral sclerosis (ALS). The objective of this scoping review is to synthesize th

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The Role of Fatty Acid-Binding Proteins in Microglial Docosahexaenoic Acid Uptake and Immunometabolism

神经退行性疾病治疗

小胶质细胞代谢

Inflammation in the brain, termed neuroinflammation, occurs very commonly in neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. Neuroinflammation is bad as it can result in cell

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Additional file 5 of Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues

亨廷顿病机制研究

差异表达RNA分析

Additional file 5. RNAseq muscle analysis file; DESeq2 analysis results.

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Transcriptome of Drosophila melanogaster third instar larval eye discs expressing GMR-Gal4>UAS-127Q and Wild type reared on normal food or food supplemented with Amalaki Rasayana (AR) or Rasa-Sindoor (RS)

神经退行性疾病治疗

转录组分析

Purpose: Feeding larvae of fly models of polyQ and other neurodegenerative disorders on AR or RS supplemented food substantially suppressed neurodegeneration. With a view to gain further insight into

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Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

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