To investigate the effects of PSENEN knockdown on γ-secretase subunits, biological behaviors, and related signaling pathways in keratinocytes

The present study was designed to use small interfering RNA (siRNA) approach to identify the effects of PSENEN silencing on human immortal keratinocyte cell line, HaCaT. The alteration of gene expression profiles after PSENEN gene silencing in HaCaT cells was investigated employing RNA-seq sequencing