Regulation of Intestinal microbiome diversity by BTLA and HVEM. Regulation of Intestinal microbiome diversity by BTLA and HVEM

The intestinal microbiome was examined from fecal pellets of animals with genetic targeting of the BTLA inhibitory receptor and the TNFR superfamily member HVEM, or in animals treated with agonist antibodies specific for BTLA. Overall design: Fecal pellets were collected from cohorts, DNA collected, and submitted for 16S sequencing and microbiome analysis. Groups consist of BTLA flox and cre expressing derivatives, HVEM flox and cre expressing derivatives, or C57BL/6 animals treated with anti-BTLA or control Ig. Each strain comparison contains replicate samples from different animals. Microbiome content was analyzed for relative differences in bacteria abundance.