RiboMotif-SSF is a comprehensive multimodal database that integrates Rfam consensus sequences, PDB high-resolution structures, and data from five major functional annotation libraries. By constructing a rigorous cross-modal mapping framework, we have successfully indexed over 1.13 million RNA motif instances with sequence-structure-function correspondences.

RNA motifs are fundamental units regulating cellular function, but existing research is limited by the relative isolation and lack of correlation between sequence, structural, and functional data. The insufficient integration of RNA motif secondary structures with linear functional sites has become a bottleneck restricting the development of high-precision prediction models. To address this gap, we launched RiboMotif-SSF—a comprehensive multimodal database integrating Rfam consensus sequences, PDB high-resolution structures, and data from five major functional annotation libraries. By constructing a rigorous cross-modal mapping framework, we successfully indexed over 1.13 million RNA motif instances with sequence-structure-function correspondences.