Transcriptomic Characterization of Inhalation Phosphine Toxicity in Adult Male Sprague-Dawley Rats (21,252 ppm x min)

To better characterize the mechanism(s) driving PH3-induced toxicity we have performed transcriptomic analysis on conscious adult male Sprague-Dawley rats following whole-body inhalation exposure to phosphine gas at three concentrations. PH3 exposure induced concentration- and time-dependent changes in gene expression across multiple tissues.为了更深入地阐明驱动磷化氢（PH3）中毒的潜在机制，我们对经全身吸入暴露于三种浓度磷化氢气体的清醒成年雄性斯普拉-道来（Sprague-Dawley）大鼠开展了转录组学分析。磷化氢暴露可在多种组织中引发浓度依赖性与时间依赖性的基因表达变化。