EBF-1 mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Here, we investigate the role of Early B-cell factor 1 (EBF1) in MSCs to support hematopoiesis. Ebf1 deletion in Cxcl12-abundant reticular (CAR) cells and PDGFRα+Sca1+CD45-CD31-Lin- (PαS) cells in the bone marrow decreases the numbers of HSCs and myeloid cells. Single cell and bulk transcriptome analysis, combined with analysis of chromatin accessibility in EBF1-deficient MSCs revealed decreased expression of adhesion molecules and altered niche composition. In consequence, HSCs exposed to the EBF1-deficient niche, exhibit altered chromatin accessibility and impaired occupancy by myeloid regulators like AP-1, ETS and IRF.
提供机构：
Max Planck Institute of Immunobiology and Epigenetics
创建时间：
2022-02-20
