Supporting Dataset for thesis - "New World vs Old World: Refining the screening, diagnosis, and prediction of oral cancer"

This data contains supporting resources for the thesis titled "New World vs Old World: Refining the screening, diagnosis, and prediction of oral cancer". The thesis was based on eight studies which were generated from the five datasets included in the files. The first dataset (RRBS Dataset) was generated following reduced representation bisulfite sequencing of salivary DNA samples obtained from patients with oral cancer and oral potentially malignant dataset. The differentially methylated CpG sites (CPG Dataset) and differentially methylated regions (DMR Datasets) are provided in different spreadsheets. The second dataset (Bayesian mapping Dataset) comprises counts of oral cancer incidence and mortality in Hong Kong from January 2013 to December 2019. The count was obtained from the CDARS data ecosystem in Hong Kong. The third dataset (Oral cancer prognosis dataset) was obtained with ethical approval from the Hospital Authority Clinical Management System (HA-CMS). It contains information about oral cavity cancer patients in Hong Kong treated at the Queen Mary Hospital from 2000 to 2019. The fourth dataset (Oral cancer screening dataset) was obtained from a community-based oral cancer screening program in Hong Kong conducted between November 2020 to June 2022. Information about demographics, lifestyle, family history, comorbidity, and expired carbon monoxide was collected at these events and presented in the dataset. The fifth dataset (Oral potentially malignant disorders dataset) was also obtained from the HA-CMS for patients with oral leukoplakia and oral lichenoid mucositis to predict malignant transformation. For all datasets, further information explaining individual variables are within the spreadsheets.

本数据集收录了题为《新世界与旧世界：口腔癌筛查、诊断及预测的精炼》的论文所依托的辅助资源。该论文基于八项研究，这些研究源自包含于文件中的五个数据集。首个数据集（RRBS 数据集）通过对口腔癌患者及口腔潜在恶性患者唾液 DNA 样本的降低代表性亚硫酸氢盐测序而生成。差异甲基化 CpG 位点（CPG 数据集）及差异甲基化区域（DMR 数据集）分别提供于不同的电子表格中。第二个数据集（贝叶斯映射数据集）包含了从 2013 年 1 月至 2019 年 12 月期间香港口腔癌发病率和死亡率的计数，该计数数据源自香港 CDARS 数据生态系统。第三个数据集（口腔癌预后数据集）在获得医院管理局临床管理系统（HA-CMS）的伦理批准后获取，其中包含 2000 年至 2019 年期间在玛丽医院接受治疗的香港口腔癌患者信息。第四个数据集（口腔癌筛查数据集）来自 2020 年 11 月至 2022 年 6 月期间在香港进行的基于社区的口腔癌筛查项目。在这些活动中收集了关于人口统计学、生活方式、家族史、合并症和一氧化碳残留量的信息，并体现在数据集中。第五个数据集（口腔潜在恶性疾病数据集）同样来自 HA-CMS，针对口腔白斑和口腔扁平苔藓黏膜炎患者进行恶性转化的预测。对于所有数据集，有关个体变量的进一步说明均包含在电子表格中。