RNA binding proteins (RBP) of the ZFP36 family limit the differentiation and effector functions of CD4 and CD8 T cells, but little is known of their expression or function in regulatory T cells (Treg)

NIAID Data Ecosystem50

Supporting data file.

自身免疫遗传学

T细胞免疫调节

Inhibitory killer cell immunoglobulin-like receptors (iKIRs) are a family of inhibitory receptors that are expressed by natural killer (NK) cells and late-stage differentiated T cells. There is accumu

Figshare2024-12-26 更新30

Characterization of A Novel CRAC Inhibitor that Potently Blocks Human T cell Activation and Effector Functions

T细胞免疫调节

CRAC抑制剂药效评估

Store operated calcium entry (SOCE) downstream of T cell receptor (TCR) activation in T lymphocytes has been shown to be mediated mainly through the Calcium Release Activated Calcium (CRAC) channel. H

NIAID Data Ecosystem70

Transcriptome analysis of antigen-specific T follicular helper (Tfh) and non-Tfh cells after Bach2 overexpression. Transcriptome analysis of antigen-specific T follicular helper (Tfh) and non-Tfh cells after Bach2 overexpression

T细胞免疫调节

转录组学分析

We identified Bach2 as factor to be expressed at low levels in Tfh cells. Induced overexpression of Bach2 in the germinal center reaction results in loss of the Tfh cell population. RNA-seq of sorted

NIAID Data Ecosystem40

mRNA and miRNA profiles of activated and resting T cells and their exosomes

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