Additional file 2: Figure S1. of The abundance of cis-acting loci leading to differential allele expression in F1 mice and their relationship to loci harboring genes affecting complex traits

Correction of mapping bias in RNA-Seq using strain specific genomic information. Figure S2. Volcano plots identifying DAE loci. Figure S3. X-linked genes expressed in forebrain and kidney show uni-parental (maternal) expression in male F1 mice. Figure S4. Validation of 20 DAE QTLs and 15 non-DAE genes in forebrain of B6/129SF1 mice. Figure S5. Validation of DAE for imprinted genes in the forebrain of B6/129SF1 mice. Figure S6. Candidate genes at QTLs show DAE in both forebrain and kidney. Figure S7. Syn3, a gene located at a QTL associated with learning behavior shows no allelic imbalance in forebrain or kidney. Figure S3 Zim3 is expressed from only the 129S chromosome in forebrain of reciprocal F1 mice, potentially due to an INDEL in 129S gDNA. (ZIP 1175 kb)

运用菌株特异性基因组信息校正 RNA-Seq 中的映射偏差。图 S2 展示识别 DAE 基因座的海盗图。图 S3 揭示了在端脑和肾脏中表达的 X 连锁基因在雄性 F1 小鼠中表现出单亲（母系）表达。图 S4 验证了 B6/129SF1 小鼠端脑中的 20 个 DAE QTL 和 15 个非 DAE 基因。图 S5 验证了 B6/129SF1 小鼠端脑中印记基因的 DAE。图 S6 显示 QTL 上的候选基因在端脑和肾脏中均表现出 DAE。图 S7 显示与学习行为相关的 QTL 上的 Syn3 基因在端脑和肾脏中未显示出等位基因失衡。图 S3 中，Zim3 在互反 F1 小鼠的端脑中仅从 129S 染色体中表达，这可能归因于 129S gDNA 中的 INDEL。文件大小：ZIP 1175 kb