Goodness-of-fit analysis for in silico versus in vivo curves.

In silico predictions for wt as well as for bnt, arm and cta/t48 mutant embryos have been compared to respective in vivo trends (Figs. 3, 4, 5, and 6) by using Pearson's and RMSSMD (root mean squared scaled deviation) measures of goodness-of-fit [26] for the mesoderm (meso), the ectoderm (ecto) and the furrow's height (height). The closer is to 1, and the closer RMSSMD is to zero, the closer the in silico predictions match the in vivo dataset. For the wild type, ectodermal goodness-of-fit has been analysed for all time instants in the experimental invagination interval (Fig. 3d–e) as well as for t>0 minutes only.