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Transcriptional Alterations in Bone Marrow Mesenchymal Stromal Cells derived from Acute Myeloid Leukemia patients (AML BM-MSC)

ChEBI2016-07-27 更新2026-07-12 收录

白血病发病机制

骨髓转录组

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-84881 数据链接链接失效反馈

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资源简介：

Transcriptional Alterations in Bone Marrow Mesenchymal Stromal Cells derived from Acute Myeloid Leukemia patients (AML BM-MSC)

应用场景：

创建时间：

2016-07-27

造血干细胞调控

白血病发病机制

Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked PHF6 gene. However, it is currently unknown how PHF6 regulates normal hematopoiesis and how

NIAID Data Ecosystem120

Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [ChIP-seq]

白血病发病机制

细胞转录调控

Normal hematopoiesis is regulated by various cytokines via the JAK-STAT signaling pathway. Gene deletion studies in mice have demonstrated the crucial role of STAT5B in the proliferation, differentiat

NIAID Data Ecosystem50

Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_CHOW]. Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_CHOW]

糖尿病肢体缺血机制

骨髓转录组

We report transcriptomic changes in bone marrow cells of systemic miR-181a2b2 KO mice in response after chow diet feeding and hindlimb ischemia Overall design: RNA-sequencing on bone marrow cells afte

NIAID Data Ecosystem40

Hematopoietic stem cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia [RNASeq_Cdx2_secondaryAML]

白血病发病机制

造血干细胞

The caudal-related homeobox transcription factor CDX2 is ectopically expressed in the majority of patients with acute myeloid leukemia (AML). We generated an inducible transgenic mouse model whereby C

NIAID Data Ecosystem70

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [BcorKrasRNA-seq]

白血病机制研究

骨髓转录组

Investigation of the transcriptional profile of Bcor?E9-10KrasG12D myeloid progenitors Overall design: Splenocytes from Bcor?E9-10KrasG12D mice were transplanted into PTPRCA recipients, after 4 weeks

NIAID Data Ecosystem50

Transcriptional Alterations in Bone Marrow Mesenchymal Stromal Cells derived from Acute Myeloid Leukemia patients (AML BM-MSC)

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