Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-2

Dkk4 transgenic mice in Tabby background lack hair follicle formation. Gene expression profiling showed significant down regulation of Shh pathway genes at E16.5 and E17.5, the secondary hair follicle induction stages. Keywords: development or differentiation design,genetic modification design To define target genes of Dkk4 during secondary hair follicle induction, we carried out microarray experiments with mouse back skin samples that from 2 developmental time points including E16.5 and E17.5 of Tabby and Tabby background Dkk4 transgenic mice.塔比（Tabby）背景的Dkk4转基因小鼠无法形成毛囊。基因表达谱分析显示，在次级毛囊诱导阶段的E16.5和E17.5时期，音猬因子（Shh）信号通路相关基因的表达显著下调。 关键词：发育或分化设计、基因修饰设计 为明确次级毛囊诱导阶段中Dkk4的靶基因，我们针对两个发育时间点（E16.5和E17.5）的塔比（Tabby）小鼠以及塔比背景Dkk4转基因小鼠的背部皮肤样本开展了微阵列实验。