Data for: Getting over it? A proteomic analysis of mechanisms driving multigenerational acclimation to organic ultraviolet filters in Daphnia magna

Organic ultraviolet filters (UVFs) such as avobenzone, octocrylene, and oxybenzone are contaminants of concern due to their widespread occurrence in aquatic environments. Previous research has demonstrated that these UVFs are toxic to aquatic invertebrates over single-generation exposures; however, data regarding long-term outcomes across generations of exposure are lacking. This study sought to identify the mechanisms of toxicity to novel UVF exposure in D. magna and subsequent responses across 5 generations of continuous exposure by quantifying proteomic changes at the end of the F0, F1, and F3 generations. A parallel study observed toxicity to novel UVF exposure (> 40 % mortality, 46 % decreased reproduction); however, toxic effects were absent after 3 generations of continuous exposure. Impaired metabolism and immune response processes were observed in the F0 generation, with decreased abundance in > 80% of altered proteins in octocrylene and oxybenzone exposures. Impairment o..., , The \"Boyd_2025_ENVIROPOLL_raw_data\" file contains the raw data for the publication titled \"Getting over it? A proteomic analysis of mechanisms driving multigenerational acclimation to organic ultraviolet filters in *Daphnia magna*\", published in *Environmental Pollution*, 2025.

### Corresponding author:

Aaron Boyd
[[e-mail]](mailto:[e-mail])
University of Alberta

All experiments were performed in the Biological Sciences building at the University of Alberta in Edmonton, Canada.

## Below are the column descriptions for the sheet \"21 d data\"

#### Column A (\"Treatment\")

OECD CTRL = OECD water without additions (water control)
DMSO CTRL = OECD water with 0.003% v/v dimethyl sulfoxide (solvent control)
AVO = Avobenzone (CAS: 70356-09-1)
OCT = Octocrylene (CAS: 6197-30-4)
OXY = Oxybenzone (CAS: 131-57-7)

#### Column B (\"Replicate\")

Assigned sample replicate number within a treatment and generation (1-5)

#### Column C (\"Generation\")

Generation identifier of each ind...,