Gastric carcinoma patients and healthy subjects

Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, with peritoneal metastasis being the prevalent form of recurrence and metastasis in advanced disease (>50%). Currently, there are limited clinical approaches for predicting and treatment of peritoneal metastasis, resulting in a 6- month average survival time. By comprehensive genome analysis will uncover the pathogenesis of peritoneal metastasis. Here we describe a comprehensive whole-genome and transcriptome sequencing analysis of one advanced gastric cancer case, including non-cancerous mucosa, primary cancer and matched peritoneal metastatic cancer. The peripheral blood is used as normal control. Gastric carcinoma patients and healthy subjects

搜集汇总

背景与挑战

背景概述

该数据集包含胃癌患者和健康受试者的样本，具体为一个晚期胃癌病例的全基因组和转录组测序数据，涵盖非癌粘膜、原发癌、腹膜转移癌以及作为对照的外周血，旨在通过基因组分析揭示胃癌腹膜转移的发病机制。