Metabolic dysfunction associated kidney disease GWAS and gsMAP

Header Explanations:SNP: Single Nucleotide Polymorphism identifier (e.g., rsID).CHR: Chromosome number where the SNP is located.BP: Base pair position of the SNP on the chromosome.MAF: Minor Allele Frequency (frequency of the less common allele, 0–0.5).A2: Other allele (reference/non-effect allele).A1: Effect allele (allele for which the effect size is estimated).i: Index/iteration number (e.g., model or subgroup identifier).lhs: Left-hand side of the SEM equation (dependent variable, e.g., trait/factor).op: SEM operator (e.g., ~ = regression, =~ = latent measurement).rhs: Right-hand side of the SEM equation (independent variable, e.g., SNP).est: Regression coefficient estimate (effect size of SNP on lhs).se_c: Standard error of the coefficient estimate (est).Z_Estimate: Z-score for the estimate (est / se_c).Pval_Estimate: P-value for the estimate (significance of est).Q: Cochran’s Q statistic (measures heterogeneity of effects across subgroups/studies).Q_df: Degrees of freedom for the Q statistic.Q_pval: P-value for Cochran’s Q (significance of heterogeneity; This folder contains gsMap output for the traits Atrial Fibrillation and Sick Sinus Syndrome on the MOSTA E16.5_E1S1 spatial transcriptomics sample. For each trait, there are three visualization subfolders: gsMap_plot/ (spatial maps showing where the trait-associated signal is enriched across the tissue section), GSS_plot/ (plots of Gene Specificity Score, GSS, illustrating where candidate genes are specifically expressed in space), and manhattan_plot/ (GWAS-style Manhattan/diagnostic plots summarizing genomic association signals). In addition, E16.5_E1S1.MOSTA_*_Gene_Diagnostic_Info.csv provides a gene-level diagnostic table (e.g., genes with their spatial annotation, summary GSS metrics such as median GSS, and correlation-style indicators linking spatial specificity to GWAS signal), while E16.5_E1S1.MOSTA_*_gsMap_Report.html is an integrated HTML report that brings together the key figures and summaries for quick interpretation and result review.