Investigating the Link Between the Anti microbial Activity and Amyloidogenic Property in Frog Peptide Uperin 3.5

Uperin 3.5 is a small peptide from an Australian frog that can both kill bacteria and form amyloid structures similar to those found in diseases like Alzheimer’s. This research explores how Uperin 3.5 switches between its helpful and harmful forms depending on its surroundings. Using computer simulations and experiments, the study shows that certain conditions make it fold into a bacteria-killing shape, while others make it clump into amyloids. These findings reveal how one molecule can act as both protector and potential threat, offering clues for designing safer antimicrobial agents and understanding amyloid-related diseases.