Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139

Phosphorylation of GPNBM at tyrosine residue Y525 upon heterodimerization with HBEGF-bound EGFR promotes, in the presence of long non-coding RNA LINC011139 (LINK-A), the recruitment of PTK6 (BRK). In addition to PTK6, LINC01139 simultaneously recruits serine/threonine kinase LRRK2 to phosphorylated GPNBM (Lin et al. 2016).

GPNBM在与其结合HBEGF的EGFR形成异源二聚体后，在酪氨酸残基Y525处发生磷酸化，进而促进长非编码RNA LINC011139（简称LINK-A）介导的PTK6（BRK）募集。除了PTK6之外，LINC01139同时募集丝氨酸/苏氨酸激酶LRRK2至磷酸化的GPNBM（参见Lin等，2016年）。