microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages. Tissue resident macrophages are notoriously heterogeneous, exhibiting discrete phenotypes as a consequence of tissue- and micro-anatomical niche-specific functions, but the molecular basis for this is not understood. Gata6 itself has been shown to be a target of multiple miR. However, microRNA transcriptome and its dependence on tissue-specific macrophage programming, such as effected by GATA6, has not been explored. We used microRNA sequencing to determine the patterns of microRNA expression in peritoneal resident macrophages at homeostasis in the absence of GATA-6 against wild type.本数据集包含野生型（wild type）与Gata6缺陷型（Gata6-deficient）组织驻留腹膜巨噬细胞的microRNA转录组（microRNA transcriptome）数据。组织驻留巨噬细胞素来具有显著异质性，其因组织及微观解剖微环境的特异性功能而呈现出差异化表型，但其背后的分子基础尚未阐明。已有研究表明，Gata6本身可作为多种microRNA（miR）的靶标。然而，目前尚未有研究探索microRNA转录组及其对组织特异性巨噬细胞编程的依赖关系，例如受GATA6调控的巨噬细胞编程模式。本研究借助microRNA测序（microRNA sequencing）技术，对比分析了稳态条件下GATA-6缺失型与野生型腹膜驻留巨噬细胞的microRNA表达谱。