Small RNA Expression in the Chorioallantois, Endometrium and Serum of Mares Following Experimental Induction of Placentitis

To better characterize placentitis, we examined the sRNA expression patterns occurring in the endometrium, chorioallantois and serum of mares. Disease was induced in 10 mares via intracervical inoculation of Streptococcus equi ssp. zooepidemicus, either with moderate or high levels of inoculum; three un-inoculated gestationally-matched mares were used as controls. Matched chorioallantois and endometrium were sampled in two locations: region 1 - main lesion by cervical star with placental separation; and region 2 - gross inflammation without placental separation. Overall design: Next-generation sequencing of two regions of the chorioallantois and endometrium in mares with and without experimentally-induced placentitis