Estimates of the substitution rate and the tMRCA of HCV for the E2 gene without HVR1 by Bayesian coalescent methods under several molecular clock and population genetic models.

aMarginal likelihoods were calculated via importance sampling using the harmonic mean of the sampled likelihoods (with the posterior as the importance distribution).
bTime of the most recent common ancestor. The numbers between brackets are the 95% lower and upper values from the highest posterior density (95%HPD).
cSubstitution rates are given in nucleotide substitutions per site per year (s/s/y). The numbers between brackets are the 95% lower and upper values from the highest posterior density (95%HPD).
***** = the model failed to converge.