官方服务：
资源简介：
DNA nicks induce mutational signatures associated with BRCA1 deficiency
应用场景：
创建时间：
2022-01-20
相关数据集
BRCA1, R-loops and Recombination defects in Ewing's sarcoma (RNA-seq)
Ewing's sarcoma family of tumors (ESFT) is an aggressive pediatric bone and soft tissue cancer. It is the prototypical example of mesenchymal tumors driven by a fusion oncogene involving the ewing sar
NIAID Data Ecosystem100
Additional file 2 of DNA double-strand break repair gene mutation and the risk of papillary thyroid microcarcinoma: a case–control study
Additional file 2. Data of Clinicopathological characteristics of Papillary Thyroid Microcarcinoma.
NIAID Data Ecosystem50
Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent
Chromosomal DNA must be in single-strand form for important transactions such as replication, transcription, and recombination to occur. The single-strand DNA (ssDNA) is more prone to damage than doub
NIAID Data Ecosystem40
RNAseq analysis of BRCA deficient tumors treated with saline, Nano-Talazoparib or Talazoparib. RNAseq analysis of BRCA deficient tumors treated with saline, Nano-Talazoparib or Talazoparib
We report the gene expression profile in BRCA deficient tumors after treatment with saline, nanoparticle-formulated Talazoparib and free Talazoparib Overall design: To study the regulation of gene exp
NIAID Data Ecosystem50
BRCA-deficient mouse mammary tumor organoids - a tool to study cancer drug resistance. BRCA-deficient mouse mammary tumor organoids
Poly(ADP-ribose) polymerase inhibition (PARPi) is a promising new therapeutic approach for the treatment of cancers that show homologous recombination deficiency (HRD). Despite the success of PARPi in
NIAID Data Ecosystem40
