mRNA Sequencing Data of Osteosarcoma Sarcospheres and Residual Cells

Study Goals and Relevance:This dataset provides raw RNA sequencing data generated from osteosarcoma cells to investigate molecular mechanisms underlying cellular dedifferentiation and pulmonary metastasis. Sarcospheres (dedifferentiated state) and adherent residual cells (differentiated state) were analyzed to identify key regulators of cytoskeletal remodeling and stemness acquisition. These data underpin findings from the associated study, which revealed thrombospondin 1 (THBS1) and integrins ITGA1/ITGA6 as critical mediators of dedifferentiation and metastasis in osteosarcoma.Associated Publication:For detailed methods, results, and conclusions, refer to the published study:Title: Thrombospondin 1 Promotes Cytoskeleton Remodeling, Dedifferentiation, and Pulmonary Metastasis through ITGA1 and ITGA6 in OsteosarcomaDOI: https://doi.org/10.7150/ijbs.93678PMID: 40083708