An antigen panel to assess the regional relevance of foot and mouth disease vaccines

Despite widespread use of inactivated vaccines to control foot-and-mouth disease (FMD), there is no systematic approach to demonstrate the regional relevance of these products against the specific serotypes and strains that circulate in endemic countries in Africa and Asia. Failure to adopt independent testing of FMD vaccines has contributed to poor trust in their quality and a lack of investment in vaccination programmes. Therefore, a reference antigen panel representing four serotypes, tailored for East Africa, has been established and used to measure FMDV-specific antibody responses in cattle after administration of FMD vaccines commercially available in the region. This revealed inconsistencies and gaps in cross-neutralisation responses that are evident for some vaccines even after giving booster doses. It is concluded that the East Africa reference antigen panel can be used to evaluate FMD vaccine potency and drive up vaccine quality. Further panels could be developed and deployed ..., , , # Data from: An antigen panel to assess the regional relevance of foot and mouth disease vaccines

## Description

### Supplementary Data 1 (SD1\_mAb\_info.xlsx file)

**Characteristics of foot-and-mouth disease virus (FMDV) monoclonal antibody (mAb) used for antigenic typing** - Murine mAbs used for antigenic typing had been prepared over many years at the WOAH FMD Reference Laboratory in Brescia, Italy (Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \"Bruno Ubertini\") and included both neutralising and non-neutralising Mabs. mAbs were raised against:

1. FMDV serotype O O/Switzerland/1965 or O Manisa lineages (*O MAN & O-1 and O UK 2001 spreadsheets*);
2. different FMDV serotype A strains (*Various Type A spreadsheet*);
3. FMDV serotype SAT 1 SAT1/BOT 1/68 lineage (*SAT1 BOT 1-68 spreadsheet*);
4. FMDV serotype SAT 2 SAT2/ZIM/5/81 lineage (*SAT2 ZIM 5-81 spreadsheet*)

### Supplementary Data 2 (SD2\_pAb\_info.xlsx file)

**Characteristics of FMDV polyclonal...,