BACE-1 in complex with a HEA-macrocyclic type inhibitor
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BACE-1 in complex with a HEA-macrocyclic type inhibitor Descriptor: Beta-secretase 1, N-[(4S,8E,11S)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl]-N-methylmethanesulfonamide Authors: Lindberg, J, Borkakoti, N, Derbyshire, D. Deposit date: 2012-02-13 Release date: 2012-07-11 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes. Bioorg.Med.Chem., 20, 2012
创建时间：
2012-02-13
