Deficiency of MIF has an influence on the gut microbiota of C57BL/6 mice infected with Plasmodium berghei ANKA

This study not only further proved the gut microbiota changes in C57BL/6 mice caused by PbA infection, but also found that MIF deletion directly affected the changes in the gut microbiota of C57BL/6 mice before and after PbA infection. This finding reveals a potential mechanism by which MIF regulates CM. The obtained potential biomarkers at the genus and species levels could act as a future research basis to explore the role and mechanism of MIF in regulating CM. Combining MIF with intestinal flora will provide a promising idea to develop combined drugs for improving CM in the future.