Genetic basis of drug resistance in Mycobacterium tuberculosis

This dataset consists of files and figures that were used to investigate the genetic basis of drug resistance in Mycobacterium tuberculosis (Mtb). Files Lineage 1.txt - Lineage 6.txt describes the most discriminative polymorphisms needed to differentiate between susceptible and resistant strains. Files Lineage_1_df.txt - Lineage_6_df.txt show all epistatic interactions that exist between the most discriminative polymorphisms. These files also provide the results of the statistical analysis done to ensure that indeed these polymorphisms were epistatically linked. The figures show a network of epistatic interactions that have established evolutionary trajectories towards drug resistance. Common_polymorphisms.v5 shows pseudo sequences of amino acids that were identified among the polymorphisms.Common_polymorphisms.v5_annotation.out shows all the annotated polymorphisms found in Mtb strains. The files_metadata file shows all the drug susceptibility profiles of all Mtb strains included for analysis. Lastly, the universal_AMR_markers show all the markers/indicators of drug resistance to more than three antibiotics.

本数据集包含用于探究结核分枝杆菌（Mycobacterium tuberculosis, Mtb）耐药性遗传基础的文件与图表。文件序列1.txt - 序列6.txt描述了区分易感菌株与耐药菌株所需的最具鉴别性的多态性。文件序列_1_df.txt - 序列6_df.txt展示了存在于最具鉴别性多态性之间的所有上位性相互作用，同时亦提供了为确保这些多态性存在上位性联系而进行的统计分析结果。图表展示了上位性相互作用网络，该网络确立了药物耐药性进化的轨迹。常见多态性_v5文件展示了在多态性中识别出的氨基酸伪序列。常见多态性_v5_注释.out文件展示了在Mtb菌株中发现的所有注释多态性。文件_metadata展示了所有用于分析的Mtb菌株的药物敏感性图谱。最后，通用抗生素耐药性标记显示了针对三种以上抗生素的耐药性标记/指示物。