Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells. Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells

All-trans retinoic acid (ATRA) alters gene expression in CCE WT embryonic stem cells, but has no effect on gene expression in RAR-deficient TKO cells (devoid of Retinoic Acid Receptors α, β, and γ) Overall design: Murine Embryonic Stem Cells (WT and RAR-deficient TKO cells) were treated with vehicle (ETOH) or all-trans retinoic acid (ATRA, 1uM) and expression profiling was performed by RNAseq