Numerical Investigation of the Mechanisms of Cyclone in Supercritical Water Environments and Dry Powder Inhalation

This thesis focuses on the investigation of cyclone separators in supercritical environments and miniature cyclones for inhalation drug delivery. The study utilizes numerical simulations to explore the behavior of particles in cyclones operating with supercritical fluid-solid flow. The effects of geometric variations and the presence of supercritical carbon dioxide on the performance of cyclones operating with supercritical fluid-solid flow are analyzed. Additionally, ten different miniature cyclones with varying structures, flow rates, and particle sizes are designed to understand their impact on the emitted dose. The study also investigates modifications to the grid structure in miniature cyclones to improve their delivery performance. Overall, this research provides valuable insights into the mechanisms of cyclone separation in supercritical environments and offers potential advancements in the design of inhaler devices for pharmaceutical applications.