Data from: Risk factors for possible REM sleep behavior disorders: a community-based study in Beijing

Objective: To explore the risk factors for idiopathic REM sleep behavior
disorder (RBD) in a community population in Beijing. Methods: Participants
aged 55 years and above were recruited from the Beijing Longitudinal Study
on Aging II (BLSA II) cohort. We identified individuals with possible RBD
(pRBD) using the validated RBD questionnaire-Hong Kong in 2010. A series
of environmental, lifestyle and other potential risk factors were assessed
via standardized questionnaires in 2009. Multivariable logistic regression
analysis was performed to investigate the association between the studied
factors and pRBD. Results: Of 7225 participants who were free of
parkinsonism and dementia, 219 (3.0%) individuals were considered as
having pRBD. Participants with pRBD reported more non-motor and motor
symptoms of Parkinson’s disease (PD) with adjusted odds ratios (ORs)
ranging from 1.10 to 4.40. Participants with pRBD were more likely to
report a family history of parkinsonism or dementia (OR 3.03, 95%
Confidence interval [CI] 1.23–7.46). There was a significant association
between pRBD and self-reported hyperlipidemia (OR 1.51, 95% CI 1.09–2.10),
ever smoking (OR 1.79, 95% CI 1.20–2.65), prior carbon monoxide (CO)
poisoning (OR 2.30, 95% CI 1.39–3.83) and nonoccupational exposure to
pesticides (OR 2.21, 95% CI 1.40–3.50). Conclusion: Our study replicated
previously reported associations between pRBD and hyperlipidemia, smoking,
pesticide exposure, and several prodromal PD symptoms. We also found
previously unreported links with a positive family history of
parkinsonism/dementia and CO poisoning. Risk factor profiles for pRBD
partially resemble those defined for PD, but also differ in distinct ways.