SAHA Rat Dental Pulp
收藏Alliance of Genome Resources2026-08-01 收录
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Transcript profiling of DPC identified several novel genes expression induced and supressed by HDACi at 24 hrs and 14 days under mineralising conditions. SAHA induces several members of the MMP family of endopepsidases (TIMP-1, MMP-9, MMP-13) and other members of the endochondral ossification pathway at 24 h.
在矿化培养条件下，对DPC进行转录谱分析后发现，24小时及14天时间点下，组蛋白去乙酰化酶抑制剂（HDACi）可诱导并抑制多个新基因的表达；辛二酰苯胺异羟肟酸（SAHA）可在24小时内诱导多个内肽酶类基质金属蛋白酶（MMP）家族成员（TIMP-1、MMP-9、MMP-13）及软骨内成骨通路的其他相关成员的表达。
