FHOD formin and SRF promote striated muscle development through separate pathways in C. elegans. FHOD formin and SRF promote striated muscle development through separate pathways in C. elegans

We show that striated muscle-expressed genes affected by reduction in UNC-120/SRF activity are not similarly affected by absence of the FHOD-1 formin. This suggests FHOD-1 does not affect striated muscle development via promotion of UNC-120/SRF-dependent transcription. Overall design: mRNA-seq was performed on the Illumina NextSeq 500 platform to measure gene expression in N2 wild-type, XA8001 fhod-1(tm2363), and RW364 unc-120(st364) L3 stage C. elegans larvae grown at 15˚C.