In Vivo Mitochondrial Base Editing Restores Genotype and Visual Function in a Mouse Model of LHON
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MitoKO: A library of base editors for precise ablation of all protein-coding genes in the mouse mitochondrial genome
We design and apply a highly optimized library of double-stranded DNA deaminase (DddA)-derived cytosine base editors (DdCBEs) - MitoKO - to precisely ablate every mtDNA protein coding gene in the mous
NIAID Data Ecosystem70
Candidate genes for FECD and related diseases of the cornea.
The columns FECD and CCT indicate whether genes have been implicated in Fuchs dystrophy and central corneal thickness, respectively. The effects on CCT are those for rare (variant) alleles; “Increased
Figshare2015-12-02 更新40
Data_Sheet_1_The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in Cryptophthalmos Development.docx
BackgroundCryptophthalmos is characterized by congenital ocular dysplasia with eyelid malformation. The pathogenicity of mutations in genes encoding components of the FRAS1/FREM protein complex is wel
NIAID Data Ecosystem30
Knockout of CMS-causative mitochondrial gene. Oryza sativa
To determine whether a mitochondrial gene orf312 causes Tadukan-type cytoplasmic male sterility using mitochondrial-targeted TALEN
NIAID Data Ecosystem60
Predictability of DdCBEs mediated base editing in mitochondrial DNA
DdCBE acts as the most commonly used editor for mtDNA, our understanding of the editing rules is very limited, especially for the aC targets, we need to optimize the editing strategies by adjusting th
NIAID Data Ecosystem40
