Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.本研究从雷公藤（Tripterygiun wilfordii Hook.）的真菌内生菌Rhinocladiella sp. lgt-3中分离得到两个新型环二肽类化合物rhinocladin A（化合物1）与rhinocladin B（化合物2）。上述化合物的结构通过一维及二维核磁共振波谱（NMR）得以解析，同时本研究还评估了化合物1和2的单胺氧化酶抑制活性。