Characteristics of mouse intestinal microbiota during acute liver injury following 50% partial hepatectomy

The gut microbiota dysbiosis plays an important role in various diseases of the host, such as obesity, diabetes, inflammatory bowel disease, autoimmune diseases, acute severe pancreatitis, hepatitis, liver cirrhosis, tumors and many other pathological states. There have been lots of studies focus on the gut microbiota changes in liver cirrhosis. With increasing understanding of the relationship between the gut microbiota and host metabolism in cirrhosis, new methods and approaches would be developed to promote the treatments and prevention of liver cirrhosis. While in carbon tetrachloride- induced acute liver injury, study showed that Firmicutes abundance increased and Bacteroidetes decreased over time, and initial alterations in the Firmicutes/Bacteroidetes ratio might be beneficial to liver repair. However, the changes of intestinal microbiota during partial hepatectomy (PH) induced acute liver injury remains unknown. We aimed to disclose the gut microbiome and its related pathways following PH induced acute liver injury.