Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, methotrexate and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid.
收藏Protein Data Bank Japan2023-09-20 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/4q0d
下载链接
链接失效反馈官方服务：
资源简介：
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, methotrexate and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid. Descriptor: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, METHOTREXATE, ... Authors: Kumar, V.P, Anderson, K.S. Deposit date: 2014-04-01 Release date: 2014-10-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.449 Å) Cite: Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorg.Med.Chem.Lett., 24, 2014
创建时间：
2014-04-01
